Supplements that have helped my positive symptoms:
Amyloban 3399, a potent form of Lion’s Mane:
Rating: 9/10 (only -1 due to the price of $110 Canadian a month)
I had 3/10 voices when I began taking it, where it was mostly quiet if I was concentrating on music, videos, or reading something, but if I was in silence or next to white noise I would hear voices. After 3 full days of it my voice intensity was down to 0.3/10, where I can’t hear any voices even if I try. Only the occasional blip was heard, but I was also on 12 mg Paliperidone (the max dose.)
I’m now at 3 weeks, and I’ve been able to stop my Paliperidone completely due to the dramatic reduction in positive symptoms I’ve experienced (please don’t do this without a doc’s approval.) I’m still on Abilify 10 mg for thought broadcasting, but I might not even need that. Abilify doesn’t cause many side effects for me so I think I’ll stick with it.
I’m feeling quite good with the medication reduction, my brain doesn’t feel like it’s too fast and I don’t feel like I’m living in a computer simulation like what happened last time I tried to reduce it that much. My brain feels blissfully slow, and I have few intrusive thoughts now.
I’m going to switch to a more affordable brand of Lion’s Mane from elsewhere (I don’t want to shill and give out a website) once I run out, but I’m feeling like I’ll be normal or close to normal by then. I don’t think this has to be taken forever, since it actually heals the brain. I would start with Amyloban 3399 though, since it has a known potency. Other brands have who-knows-what in them.
Lion’s Mane works by increasing Nerve Growth Factor in the brain, which may heal the damage that is causing schizophrenia symptoms.
There is a study showing that it works on refractory schizophrenics. Another study had a person go from a PANSS (positive and negative schizophrenia symptoms) score of 62 (moderately ill) to 30 (normal) in two weeks of taking it.
Rating: 6/10 (seems to work better than placebo at taking the edge off the voices)
It’s cheap and moderately effective. It tilts tryptophan metabolism away from kynurenic acid formation by increasing the amount of kynurenine 3-monooxygenase formed. Excessive kynurenic acid is one of the hypothesized causes of schizophrenic symptoms now, since it is a potent NMDA antagonist.
Downside is you have to keep taking it. It does increase brain-derived neurotrophic factor so there may be some cumulative benefit to it.
Supplements that I’ve tried but didn’t make much difference:
Ashwagandha: Didn’t feel much calmer. Not a huge difference. Kind of placebo-ish.
Sarcosine: I felt a little more energetic, but the prostate cancer correlation made me stop taking it.
N-Acetylcystine: Not a life changer. Felt somewhat calmer?
Glycine: Not a huge change, felt somewhat more energetic.