Family and Caregiver Schizophrenia Discussion Forum

Supplements that have helped with my schizophrenia (almost fully in remission now)


Supplements that have helped my positive symptoms:

Amyloban 3399, a potent form of Lion’s Mane:

Rating: 9/10 (only -1 due to the price of $110 Canadian a month)

I had 3/10 voices when I began taking it, where it was mostly quiet if I was concentrating on music, videos, or reading something, but if I was in silence or next to white noise I would hear voices. After 3 full days of it my voice intensity was down to 0.3/10, where I can’t hear any voices even if I try. Only the occasional blip was heard, but I was also on 12 mg Paliperidone (the max dose.)

I’m now at 3 weeks, and I’ve been able to stop my Paliperidone completely due to the dramatic reduction in positive symptoms I’ve experienced (please don’t do this without a doc’s approval.) I’m still on Abilify 10 mg for thought broadcasting, but I might not even need that. Abilify doesn’t cause many side effects for me so I think I’ll stick with it.

I’m feeling quite good with the medication reduction, my brain doesn’t feel like it’s too fast and I don’t feel like I’m living in a computer simulation like what happened last time I tried to reduce it that much. My brain feels blissfully slow, and I have few intrusive thoughts now.

I’m going to switch to a more affordable brand of Lion’s Mane from elsewhere (I don’t want to shill and give out a website) once I run out, but I’m feeling like I’ll be normal or close to normal by then. I don’t think this has to be taken forever, since it actually heals the brain. I would start with Amyloban 3399 though, since it has a known potency. Other brands have who-knows-what in them.

Lion’s Mane works by increasing Nerve Growth Factor in the brain, which may heal the damage that is causing schizophrenia symptoms.

There is a study showing that it works on refractory schizophrenics. Another study had a person go from a PANSS (positive and negative schizophrenia symptoms) score of 62 (moderately ill) to 30 (normal) in two weeks of taking it.


Rating: 6/10 (seems to work better than placebo at taking the edge off the voices)

It’s cheap and moderately effective. It tilts tryptophan metabolism away from kynurenic acid formation by increasing the amount of kynurenine 3-monooxygenase formed. Excessive kynurenic acid is one of the hypothesized causes of schizophrenic symptoms now, since it is a potent NMDA antagonist.

Downside is you have to keep taking it. It does increase brain-derived neurotrophic factor so there may be some cumulative benefit to it.

Supplements that I’ve tried but didn’t make much difference:

Ashwagandha: Didn’t feel much calmer. Not a huge difference. Kind of placebo-ish.

Sarcosine: I felt a little more energetic, but the prostate cancer correlation made me stop taking it.

N-Acetylcystine: Not a life changer. Felt somewhat calmer?

Glycine: Not a huge change, felt somewhat more energetic.


Thank you. I’ve never heard of Lion’s Mane. I have heard that niacin or niacinamide might help. I guess I should try to get my daughter on supplements again, now that she is medicated she is more agreeable to suggestions that are good for her.


Can you share the study that you have found? I’m interested in other ways to help my son recover.


The studies are available as hyperlinks on my post. Here are the study URLs:



This really excites me! I love to hear of innovative approaches that are working for people. Although I don’t have schizophrenia, I do take lion’s mane and can attest to the positive benefits for memory and focus. My daughter is schizophrenic so I will definitely look into this.


This is interesting information. My son is living at the hospital right now and I have absolutely no influence over what meds he gets. I do know that are not the least interested in letting him take simple vitamins to enhance his health. He got them to give him 1000 of VIt D and Vit C daily but wouldn’t give him B vitamins or good quality fish oil, supplements he was taking at home. He has also learned that he can’t even talk about alternative treatments while he is there- it makes them suspicious that he will not be med compliant when he leaves.
Between that and the lack of really good food, his physical health is taking a hit. We were all so thankful that he was recovering and doing well at the hospital initially, and he still is, but it’s frustrating when he wants to take more control over and interest in his health and the roadblocks are so big.
It’s a journey- but I’m still wanting to learn more about alternative/additional treatments.