Hi. My son has always taken the pills along with shots because when this all started, he was spitting the pills out behind my back, hiding them and everything else he could do to not take them. Then he refused the pills when he turned 18. Ended up in hospital and they gave him the shot. They kept him 7 months and he started taking the pills to come home. His doctor has never mentioned not taking them. But in summer 2016 he didn’t want the shot and we stopped it and he had an episode ending up with police taking him to hospital. That’s when they changed him from respirodol to Haldol along with the shot. It may be different for different people but he has been on Haldol 10 mg with shot since 2016. Hope this helps.