Good suggestion. I searched for “poly” in the document and found this in a footnote: Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia
This table shows that quetiapine monotherapy is very much worse than olanzapine monotherapy, which is very slightly worse than quetiapine and olanzapine together, which is what my son is on. Doesn’t say anything about levels of dosing though.
Also this:
The risk of psychiatric hospitalization, all-cause hospitalization, or death was not decreased significantly by adding any miscellaneous antipsychotic (most of those other than aripiprazole) to clozapine. However, including any other agent with quetiapine, which had the worst monotherapy response, resulted in a better outcome. At an aggregate level, the risk of psychiatric rehospitalization was 7% lower during any polypharmacy than any monotherapy period without censoring the first 90-day periods of antipsychotic treatment