Good ole Cyanide and Happiness. Love their stuff. I have 3 books by them and have been a fan since ~2008. Did you just get this on your Facebook feed? I saw this a day or two ago.
I love them!
Have you ever seen Saturday Morning Breakfast Cereal? He does mainly science based jokes. Not stuff that you have to be super knowledgeable about. Some of the harder stuff he says in such a way that you understand it even if you know nothing about it.