My son has been on 20 mg of olanzapine and 600 mg of quetiapine for about 6 weeks. He says he’s feeling better than he ever has regarding voices and delusions. The voices have about totally gone away and he says that he’s not thinking delusional thoughts.
I’m pretty sure he’s gaining some weight but don’t know exactly how much.
His psychiatrist has said that he might start tapering the quetiapine and probably would if my son wanted him to, but I don’t think he does because he says he’s terrified of the voices coming back.
I have yet to find anything that says taking this amount of drugs is a good idea. This paper: High Dose Antipsychotic Therapy (HDAT) (In patients aged 18 years and over) says it is not a good idea and combination treatments should be limited to an equivalent 100% maximum dose. The paper provides a table at the end:
which shows that 10 mg of olanzapine and 375 mg of quetiapine is what would be safe and effective.
Has anyone else had experience with psychiatrists prescribing more than the maximum dose of APs either alone or in combination?