My nephew aged 21 yrs has been suffering from/diagnosed with Schizophrenia for the past 1.5 - 2 yrs. His doctor initially treated him with a variety of antipsychotics but they having no effect on him, started Clozapine treatment on Jan 8th 2014. His dosage was increased to 400 mg/day starting beginning of Feb. And now, it being 12th March, the doctor feels that it is kinda delayed for my nephew to not show any improvement at all and fears he could be treatment-resistant. On browsing around the net, I found that sometimes responsiveness to Clozapine takes longer… Do members here have idea on how fast or slow Clozapine treatment would give responsiveness? Also, what treatment options are available for those who are ‘resistant’ to Clozapine?