I’ve seen this new schizophrenia drug advertised on television recently. It is supposed to be a once-a-day pill for schizophrenia. Does anyone know anything about it, or have any loved-ones who have tried it yet? If so, how has it worked for them?
Thanks!
I would like to know this as well.,
I just found this “The exact way Caplyta works is unknown but it is thought to affect the balance of these brain-signaling chemicals to help control schizophrenia symptoms.” Unbelievable! We have no idea how it works, but go ahead and take this. Of course I think most of us would have our loved ones on anything, as long as it worked.
To my knowledge there’s no definitive known mechanisms why any AP medications work. They don’t know what causes the disease(s) and can’t agree whether it’s one or a multitude of diseases and whether they exist on a spectrum.
They have various theories and know and can observe which receptors respond to medications, but it’s theorized that our brains may be incapable of understanding how they themselves work, and since these are brain disorders, it follows the mechanisms of the diseases may never be fully understood.
Caplyta, aka lumateperone was released I believe Dec 2019. I followed the clinical trials online and the final results seemed promising. Although the side effects listed are the same as most AP medications, I did read that the weight gain was similar to placebo. I believe it effects all 3 neurotransmitters, dopamine, serotonin, and glutamate. You can read about it on the FDA.gov website.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-caplyta
As my son’s side effects continue to progress and medication change is needed, this is the medication we are reviewing and considering. It is compatible with his DNA so we are hopeful it will work when the risk of change is lesser then his medication effectiveness .
I remind my son to hang on, fight hard and know that new medications are being evaluated and released all the time. The scientists are working hard to understand MH disorders. Computers and technology are beginning to give them greater insight to the brain.
As caregivers, we can continue to educate ourselves, advocate for our loved ones and maintain hope that effective treatment will be within our loved ones lifetime.
@karegiver @Maggotbrane @AllthingsRpossible “Future:
The availability of the very new resource of the sequenced human genome is challenging our field to take advantage of this critical genetic information.” The biology of schizophrenia - PMC
“Intriguingly, a large number of genes coding for ionotropic and metabotropic receptors for various neurotransmitters-glutamate, γ-aminobutyric acid (GABA), dopamine, serotonin, acetylcholine and opioids-and numerous ion channels were associated with SCZ.”
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia - PubMed
Scientific research gives hope!